The spike protein in the vaccine can lead to the development of multiple, tiny blood clots because it becomes part of the cell wall of your vascular endothelium; these cells are supposed to be smooth so that your blood flows smoothly, but the spike protein means there are “spiky bits sticking out”.. The long-term outlook is very grim, Hoffe said, because with each successive shot, it will add more damage as you’re getting more damaged capillaries